| Termijn | Thuis | Uitteam | Uitslag |
|---|---|---|---|
| 21-1-25 18:45 | AS Monaco | Aston Villa | 1:0 |
| 21-1-25 18:45 | Atalanta Bergamo | SK Sturm Graz | 5:0 |
| 21-1-25 21:00 | FC Liverpool | OSC Lille | 2:1 |
| 21-1-25 21:00 | Atletico Madrid | Bayer 04 Leverkusen | 2:1 |
| 21-1-25 21:00 | Club Brugge | Juventus Turin | 0:0 |
| 21-1-25 21:00 | Roter Stern Belgrad | PSV Eindhoven | 2:3 |
| 21-1-25 21:00 | SK Slovan Bratislava | VfB Stuttgart | 1:3 |
| 21-1-25 21:00 | FC Bologna | Borussia Dortmund | 2:1 |
| 21-1-25 21:00 | Benfica Lissabon | FC Barcelona | 4:5 |
| 22-1-25 18:45 | Schachtjor Donezk | Stade Brest 29 | -:- |
| 22-1-25 18:45 | RB Leipzig | Sporting Lissabon | -:- |
| 22-1-25 21:00 | FC Arsenal | Dinamo Zagreb | -:- |
| 22-1-25 21:00 | AC Mailand | FC Girona | -:- |
| 22-1-25 21:00 | Real Madrid | FC Red Bull Salzburg | -:- |
| 22-1-25 21:00 | Paris St. Germain | Manchester City | -:- |
| 22-1-25 21:00 | Celtic Glasgow | Young Boys Bern | -:- |
| 22-1-25 21:00 | Feyenoord Rotterdam | FC Bayern München | -:- |
| 22-1-25 21:00 | Sparta Prag | Inter Mailand | -:- |